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Gout - Medicines That Are Very Helpful

The medicines that are commonly used in alleviating the pain and other gout symptoms include:

- Adrenocorticotrophic hormone (ACTH)

- Allopurinol

- Colchicines

- Corticosteroids

- Non-steroidal anti-inflammatory drugs (NSAIDS)

- Probenicid

- Sulfinpyrazone

The first medication that is commonly prescribed in the acute cases of gout is the NSAIDS. The most effective one is Indomethacin. These drugs are initially prescribed in the highest dosage, and as symptoms subside the dosage is gradually reduced. The medicine needs to be continued until the pain and the inflammation vanish and remain so for over 48 hours. NSAIDS may have toxic effects if used for long, but when administered short term, they are well tolerated.

Allopurinol (marketed under the brand name Zyloprim) is a prescription medicine that functions in allaying by preventing the synthesis of uric acid in the body. It is very beneficial for chronic gout or gouty arthritis. The use is more preventive in nature, and it is not administered if the gout attack sets in. side effects include skin eruptions, inflammation of the blood vessel, and liver toxicity. Alterations in the enzyme profile of the liver, as for instance, transient increase in the level of alkaline phospahatase, have been reported. In other patients, incidences of hepatomegaly, necrosis of liver, hepatitis and jaundice have been known to occur.

Colchicine is a prescription medicine used to assuage acute gout attacks and to prevent recurrence of attacks as well. However it does not lower the levels of uric acid in the body. It provides relief by reducing inflammation. Serious side effect have been reported that include various stomach troubles like cramps, nausea, diarrhea, bone marrow problems, muscular inflammations, severe anemia, and serious reduction in the count of WBC, increasing the risk of secondary infections. Excessive high doses can prove to be fatal. Patients with reduced kidney function should avoid colchicines.

Patients who are intolerant to NSAIDS or Colchicine can be treated with ACTH or Corticosteroids. Patients suffering from acute gout take daily doses of Prednisone for 1 t 4 days, and then the dosage is lessened over the period of one or two weeks. ACTH is injected intramuscularly.

Probenicid is sold under the brand names Benemid or Probalan. It is prescribed for chronic gout and to prevent attacks. It is a uricosuric agent that accts on the kidney and aids in the elimination of uric acid from the system.

Sulfinpyrazone, sold under the brand name Anturane is another uricosuric agent that works by reducing the amount of uric acid in the blood, thereby preventing gout attacks.

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